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Prostate Study

http://medcraveonline.com/MOJCR/MOJCR-02-00022.pdf

This research has been presented at the International Pain Conference in Chicago, June 7-10, 2015 Chicago, IL.

http://painmedicine.conferenceseries.com/organizing-committee.php

Dr. George Grant hass completed a clinical study for 24 subjects using all natural herbal formula over 6 months to reduce the symptoms of enlarged prostate and elevated PSA.

Preventing Prostate Cancer Diet and Lifestyle Modification

Given the reality that PSA screening for early detection for prostate cancer is a misguided adventure which leads to over diagnosis and does more harm than good, perhaps another approach to prevention is warranted. A nutritional program for prostate cancer prevention with Vitamins C, B6, E, zinc, selenium, Saw palmetto, Pygeum africanum, stinging nettle, pumpkin seed, Echinacea purpurea, garlic, ginkgo biloba, Amino acids L glycine, L alanine, L glutamic acid and Modified Mediterranean Diet.

More on Prostate Health: http://www.your101ways.com

Evaluating the efficacy of IPM [Ionic Polymer Matrix] made with Hyaluronic Acid [HA] with natural herbal ingredients in the reduction of prostatis [Prostate Inflammation] for 12 male subjects over 3 months.

Dr. George Grant, Ph.D., I.M.D., D.H.S., M.Sc., M.Ed., C.B.S., C.Chem, R.M.

Dr. George Grant discusses the results of a case study to evaluate the efficacy of IPM transdermal cream made with hyaluronic acid along with natural herbal ingredients in the reduction of prostate inflammation over 3 months for 12 male subjects ranging from mid-forties to mid-seventies.

Abstract:

After using the natural IPM transdermal cream for 3 months by 12 volunteer subjects, the improvement in the reduction of frequent urination during the day and at night was over 12.5% using both biofeedback and PSA testing.
Using natural herbal formula to reduce BPH instead of using prescription medications with unpredictable and sometimes serious side effect is an innovative approach with promising successful management of BPH among men.

Patent Assignment:

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SUBMISSION TYPE: NEW ASSIGNMENT
NATURE OF CONVEYANCE: ASSIGNMENT
CONVEYING PARTY DATA
Name Execution Date
Dr. George Grant 07/08/2013
RECEIVING PARTY DATA
Name: Glyco Bio Sciences, Inc.
Street Address: 10 Mountainview Road South
Internal Address: Suite 207, City: Georgetown, CANADA, L7G 4J9
PROPERTY NUMBERS Total: 1
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Application Number: 61810380
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http://epas.uspto.gov/com/receipt.jsp?iname=VJHNRT1QQB8U-8162 07/11/2013CORRESPONDENCE DATA
Fax Number: 2484407300
Phone: 2484305772
Email: patdocketing@bluefilamentlaw.com
Correspondent Name: Avery Goldstein
Address Line 1: 450 north Old Woodward
Address Line 2: First floor
Address Line 4: Birmingham, MICHIGAN 48009
ATTORNEY DOCKET
NUMBER: GLYC-105PRV
NAME OF SUBMITTER: Avery Goldstein
Signature: /Avery Goldstein/
Date: 07/11/201

Conflict of interest disclosure: The author is not employed nor compensated by Glyco Bio Sciences the manufacture of the IPM matrix. The company provided the transdermal matrix at no charge to conduct the case study for 12 subjects at our clinic in Toronto, ON Canada. The author has no financial interest in the company.

Subject Selection Criteria: 12 healthy male subjects with mild to moderate enlarged prostate were selected to participate in this case study and signed an informed consent. Subjects with medical, psychiatric conditions and those with heavy medications were excluded from the study.
Subjects were tested using bio feedback device before and after using the IPM transdermal matrix and a fasting 12 hours CBC blood test to measure PSA levels was obtained from each subject before and after 3 months at the completion of the case study.

Objectives of the Study:

The main purpose of this research is to evaluate the efficacy of the IPM/HA Matrix with natural herbal ingredients to reduce the symptoms of enlarged prostate [BPH] in 12 subjects over 3 months.

Introduction, Protocol and Description of the Research:

The following natural herbal ingredients were encapsulated in HA gel and applied transdermally once every night before bed time:

Turmeric/Curcumin 100 mg: Curcumin, an active ingredient of the Indian spice Turmeric, has been shown to stop the formation of metastases in prostate cancer patients, researchers from LMU University in Munich, Germany, reported in the journal Carcinogenesis today.

Beta Sitosterol 100mg: Beta Sitosterol is a phytosterol, which means it is a phytochemical that occurs naturally in many plants.

prostate
prostatestudyrevised



Fat Content and Cardiovascular Disease
Dairy productsincluding cheese, ice cream, milk, butter, and yogurtcontribute significant amounts of cholesterol and saturated fat to the diet.15 Diets high in fat and especially in saturated fat can increase the risk of heart disease and can cause other serious health problems.

A low-fat, plant-based diet that eliminates dairy products, in combination with exercise, smoking cessation, and stress management, can not only prevent heart disease, but may also reverse it.

The danger of dairy product consumption as it relates to prostate and breast cancers is most likely related to increases in insulin-like growth factor (IGF-1), which is found in cows milk. Consumption of milk and dairy products on a regular basis has been shown to increase circulating levels of IGF-1. Perhaps the most convincing association between IGF-1 levels and cancer risk is seen in studies of prostate cancer. Case-control studies in diverse populations have shown a strong and consistent association between serum IGF-1 concentrations and prostate cancer risk. One study showed that men with the highest levels of IGF-1 had more than four times the risk of prostate cancer, compared with those who had the lowest levels.26 In the Physicians Health Study, tracking 21,660 participants for 28 years, researchers found an increased risk of prostate cancer for those who consumed ≥2.5 servings of dairy products per day as compared with those who consumed 0.5 servings a day. This study, which is supported by other findings, also shows that prostate cancer risk was elevated with increased consumption of low-fat milk, suggesting that too much dairy calcium, and not just the fat associated with dairy products, could be a potential threat to prostate health.

In addition to increased levels of IGF-1, estrogen metabolites are considered risk factors for cancers of the reproductive system, including cancers of the breasts, ovaries, and prostate. These metabolites can affect cellular proliferation such that cells grow rapidly and aberrantly, which can lead to cancer growth. Consumption of milk and dairy products contributes to the majority (60-70 percent) of estrogen intake in the human diet.

In a large study including 1,893 women from the Life After Cancer Epidemiology Study who had been diagnosed with early-stage invasive breast cancer, higher amounts of high-fat dairy product consumption were associated with higher mortality rates. As little as 0.5 servings a day increased risk significantly. This is probably due to the fact that estrogenic hormones reside primarily in fat, making the concern most pronounced for consumption of high-fat dairy products.

The consumption of dairy products may also contribute to development of ovarian cancer. The relation between dairy products and ovarian cancer may be caused by the breakdown of the milk sugar lactose into galactose, a sugar which may be toxic to ovarian cells. In a study conducted in Sweden, consumption of lactose and dairy products was positively linked to ovarian cancer. A similar study, the Iowa Women’s Health Study, found that women who consumed more than one glass of milk per day had a 73 percent greater chance of developing ovarian cancer than women who drank less than one glass per day.

Prostate cancer is one of the most common cancers in men. According to the latest statistics, about 181,000 men get diagnosed with prostate cancer every year in the U.S.

However, while common, it has a survival rate of about 86 percent. Of those diagnosed, about 26,000 die from the disease each year.1

Unfortunately, conventional diagnostics and treatment options for prostate cancer leave much to be desired. Conventional diagnosis includes PSA testing and biopsy, which are prone to false positives and carry risks of side effects.

Treatment typically involves drugs, surgery and/or radiation, all of which are risky. There ARE safer, less invasive ways to diagnose and treat prostate cancer, however, so men would be wise to investigate their options.

Last year, I interviewed award-winning filmmaker and prostate cancer survivor Peter Starr on this topic, which is also covered in his latest documentary, “Surviving Prostate Cancer Without Surgery, Drugs or Radiation.”2

A number of safe and all-natural strategies have been shown effective against prostate cancer, including nutritional ketosis, exercise and supplements. Most recently, researchers discovered a bioactive compound in the neem plant (Azadirachta indica) appears to have potent ability to quell prostate cancer.

Neem Has a Long History of Medicinal Use

Neem has been used in Ayurvedic medicine for thousands of years, and the ancient Vedas refer to neem as a tree “capable of curing every illness.” It has well-established benefits for your skin, and is commonly used in personal care products.3

It also is used to ease gastrointestinal problems and strengthen immune function, and as both a spermicide and an insect repellent. As noted in the Biojournal of Science and Technology (BJST):4

“[Neem’s] leaves, barks, fruits, seeds and roots contain compounds with proven anti-inflammatory, anti-pyretic, anti-histamine, anti-fungal, antibacterial, anti-ulcer, analgesic, anti-arrhythmic, anti-tubercular, anti-malarial, diuretic, spermicide, anti-arthritic, anti-protozoal, insect repellant, anti-feedant, anti-hormonal properties and anti-cancerous uses.

From various research articles it can be presumed that [neem] has chemopreventive and chemotherapeutic potential against cancer models [including] acting against the breast cancer cells, against gastrointestinal tract and associated cancers [and] ovary cancer cells.”

Neem May Be a Potent Ally Against Prostate Cancer

Now, animal research suggests nimbolide a bioactive terpenoid compound found in neem may shrink prostate tumors by as much as 70 percent, and suppress metastasis by about 50 percent when taken orally for three months.5,6,7,8 No noticeable side effects were observed.

According to lead researcher Gautam Sethi, Ph.D., associate professor of pharmacology at the Yong Loo Lin School of Medicine at the National University of Singapore:9

“Although the diverse anti-cancer effects of nimbolide have been reported in different cancer types, its potential effects on prostate cancer initiation and progression have not been demonstrated in scientific studies.

In this research, we have demonstrated that nimbolide can inhibit tumor cell viability a cellular process that directly affects the ability of a cell to proliferate, grow, divide or repair damaged cell components and induce programmed cell death in prostate cancer cells

[A] direct target of nimbolide in prostate cancer is glutathione reductase, an enzyme which is responsible for maintaining the antioxidant system that regulates the STAT3 gene in the body.

The activation of the STAT3 gene has been reported to contribute to prostate tumor growth and metastasis. We have found that nimbolide can substantially inhibit STAT3 activation and thereby abrogating the growth and metastasis of prostate tumor.”

Other Research Supporting Neem as an Anti-Cancer Aid

While exceptionally promising in rodents, nimbolide has not yet been tested in humans, so further research will be required. The team intends to continue investigating the compound to evaluate its efficacy in combination with commonly used prostate cancer drugs as well.

That said, consuming neem either in supplement or tea form will automatically provide nimbolide.

Even though the whole herb will provide only a small amount of nimbolide (compared to the straight compound given to the animals in this study), previous research has indeed found neem extract to be useful against prostate cancer. In 2006, researchers reported that:10

“[A]n ethanolic extract of neem has been shown to cause cell death of prostate cancer cells by inducing apoptosis as evidenced by a dose-dependent increase in DNA fragmentation and a decrease in cell viability So the neem extract could be potentially effective against prostate cancer “

Lifestyle and Prostate Cancer

Treating and preventing prostate cancer (and other cancers) requires more than taking a supplement. Your diet is a vital part of the healing equation and exercise is another important metabolic optimizer.

Previous research suggests losing weight can reduce your risk of prostate, breast and colon cancer by as much as 20 percent, and this effect is thought to be due to reductions in these proteins and other inflammatory compounds stored in fat cells.11

According to a 2011 study published in PLoS One,12 aggressive prostate cancer was associated with obesity.

Another cohort study published in Cancer Epidemiology, Biomarkers & Prevention13in 2013 found that men who were overweight or obese increased their risk of prostate cancer by 57 percent.

Here, the association between obesity and prostate cancer held for all cases low-grade and high-grade, early stage and late, nonaggressive and aggressive prostate cancer.

When it comes to exercise, research suggests maintaining a high level of cardiorespiratory fitness (CRF) in middle age helps cut men’s chances of dying from prostate cancer by nearly one-third (32 percent).14,15

Exercise reduction of cancer is most likely related to improving insulin receptor sensitivity and PGC 1-alpha that increases mitochondrial biogenesis.

Optimizing your vitamin D level, which is ideally done through sensible sun exposure, is another key ingredient for cancer prevention. Vitamin D deficiency has been linked to several common cancers, including cancers of the breast, colon and prostate.

Researchers at Northwestern University Feinberg School of Medicine recently discovered that men diagnosed with aggressive prostate cancer tend to have vitamin D levels below 23 nanograms per milliliter (ng/ml). According to this study, vitamin D may actually be used as a biomarker to predict cancer:

“[B]ecause vitamin D is a biomarker for bone health and aggressiveness of other diseases, all men should check their levels, [lead investigator Dr. Adam] Murphy said.’All men should be replenishing their vitamin D to normal levels,’ Murphy said. ‘It’s smart preventive health care.'”

You can also improve your benefit from vitamin D by increasing your healthy levels through sensible sun exposure and not by swallowing it.

Other Important Anti-Cancer Nutrients

In addition to vitamin D, vitamin K2 appears to be a noteworthy player in prostate cancer.

German doctors evaluating the effect of vitamins K1 and K2 on the development and treatment of prostate cancer found that those who consumed the greatest amount of K2 had a 63 percent reduced incidence of advanced prostate cancer.16,17

Vitamin K1 intake did not offer any prostate benefits. Other nutrients and foods shown to influence your prostate cancer risk include (but are not limited to) the following:

Foods rich in omega-3 fats have been shown to prevent prostate cancer from spreading.

One clinical study18 published in 2006 found that while omega-6 fats (the kind found in most vegetable oils) increased the spread of prostatic tumor cells into bone marrow, the spread of cancer cells was BLOCKED by omega-3 fats, suggesting that a diet rich in omega-3 fats could potentially inhibit the disease in men with early stage prostate cancer.

A more recent meta-analysis19 of available research, published in 2010, found that fish consumption was associated with a 63 percent reduction in prostate cancer-specific mortality, even though no association between fish consumption and a significant reduction in prostate cancer incidence could be found. This is related to the fact that toxin-free seafood is the ideal source of DHA, not omega-3 fats from plants that are poorly converted to DHA.

Sulforaphane found in cruciferous vegetables like broccoli has been shown to cause apoptosis (programmed cell death) in prostate cancer cells.20 Three servings of broccoli per week may reduce your risk of prostate cancer by more than 60 percent.21

Supplements That Support Prostate Health

Besides neem extract, other nutritional supplements that promote prostate health may be helpful in the prevention and/or treatment of prostate cancer, such as:

Saw palmetto. This herb is widely used to improve prostate health, and can help raise testosterone by inhibiting up-conversion to dihydrotestosterone (DHT) by as much as 40 percent.22 As explained by drug industry insider Rudi Moerck, Ph.D., (see hyperlink above), while many conventional experts believe elevated testosterone can promote prostate cancer, this risk appears more strongly correlated to the testosterone breakdown product DHT.

Testosterone levels in healthy men typically decline with age, which is one of the factors involved in prostate cancer, as your prostate gland requires testosterone to remain healthy. One doctor who is trying to re-educate people on this point is Harvard-based Dr. Abraham Morgentaler. He has meticulously demonstrated that restoring testosterone levels in aging men does not increase their risk of prostate cancer.

On the contrary, those with low testosterone are the ones at greater risk.For an interesting article that contains a lot more information about this, read Abraham Morgentaler’s report “Destroying the Myth About Testosterone Replacement and Prostate Cancer.”23

While the evidence is limited, a small number of laboratory studies suggest saw palmetto may be helpful against prostate cancer by targeting mitochondria, activating the apoptopic pathway and reducing inflammation.24,25

When choosing a saw palmetto supplement, be sure to look for an organic supercritical CO2 extract of saw palmetto oil, which is dark green in color. Since saw palmetto is a fat-soluble supplement, taking it with a small amount of healthy fat, such as coconut oil, MCT oil, avocado or eggs, will enhance the absorption of its nutrients.

A more recent meta-analysis of available research, published in 2010, found that fish consumption was associated with a 63 percent reduction in prostate cancer-specific mortality, even though no association between fish consumption and a significant reduction in prostate cancer incidence could be found. This is related to the fact that toxin-free seafood is the ideal source of DHA, not omega-3 fats from plants that are poorly converted to DHA.

Astaxanthin in combination with saw palmetto. Research suggests taking astaxanthin in combination with saw palmetto can provide significant synergistic benefits. One 2009 study found that an optimal dose of saw palmetto and astaxanthin decreased both DHT and estrogen while simultaneously increasing testosterone.26

Ashwagandha. This ancient Indian herb is known as an adaptogen, which can help boost stamina, endurance and sexual energy. Research published in 201027 found that men taking the herb Ashwagandha experienced a significant increase in testosterone levels. I recommend using only 100 percent organic Ashwagandha root, free of fillers, additives and excipients, to ensure quality.

Toxins May Increase Your Prostate Cancer Risk

Avoiding toxins is also important. As with breast cancer, many of the chemicals that are ubiquitous in our homes and environment have been shown to increase your risk of cancer. Some of the most common culprits are those that disrupt your endocrine function.

Based on a review of more than 1,300 studies, an Endocrine Society task force recently issued a new scientific statement28,29 on endocrine-disrupting chemicals, noting that everyone needs to take proactive steps to avoid them.

Similarly, a report30 co-produced by the World Health Organization (WHO) and the United Nations Environment Program (UNEP), issued in February 2014, suggests an outright ban on endocrine disrupting chemicals may be needed to protect the health of future generations.

Touted as the most comprehensive report on endocrine disrupting chemicals to date, it highlights a wide variety of health problems associated with exposure, including prostate cancer. Some of the most ubiquitous endocrine disrupters to watch out for include:

Atrazine.31 This herbicide is the second most commonly used agricultural chemical, and one of the most common water contaminants in the U.S.Atrazine is a potent endocrine disruptor, and studies show it can chemically castrate and feminize wildlife, and may induce both prostate and breast cancer.

Phthalates

Bisphenol-A and bisphenol-S (BPA and BPS). BPA, which mimics the hormone estrogen, has been linked to increased prostate size, decreased sperm production, hypospadias32 (penis deformation), erectile dysfunction33 and stimulation of prostate cancer cells.

Be aware your exposure may be far greater than you ever suspected. A 2011 study34 found that simply eating canned soup for five days increased study participants’ urinary concentrations of BPA by more than 1,000 percent compared to eating freshly made soup.

Should You Get Screened for Prostate Cancer?

According to a report by the Institute of Medicine, approximately 30 percent of all medical procedures, tests and medications may be unnecessary.35 The American Academy of Family Physicians’ (AAFP) “Choosing Wisely” campaign has also identified more than a dozen procedures that appear to have little value, and in many cases do more harm than good.36 Included in this list is routine screening for prostate cancer using a prostate-specific antigen (PSA) test.

The PSA test tends to result in over-diagnosis of prostate tumors, many of which are benign and do not actually require treatment. The U.S. spends $10 billion per year treating prostate cancer, but studies suggest the 30 million men who get screened annually for prostate cancer are actually put at risk due to the ridiculously high numbers of false positives.

According to the Prostate Cancer Foundation, 30 to 40 percent of men treated for prostate cancer actually have harmless tumors that would never have caused a problem.37 As noted by Dr. Jessica Herzstein, a preventive-medicine consultant and member of the U.S. Preventive Services Task Force, “You’re going to die with them, not of them.”

Estimates suggest 15 prostates must be removed in order to prevent just ONE prostate cancer death, and these surgical procedures carry serious side effects including impotence and incontinence.

More than half of older men have pathologic evidence of prostate cancer, so PSA screening makes little sense. The PSA is an indicator of inflammation, and inflammation can be an indicator of health problems besides prostatitis, benign prostatic hyperplasia or cancer. It’s certainly not a definitive test, and should not be the sole basis for the decision to do a biopsy, as the biopsy itself can cause significant damage.

One alternative is to get an annual digital rectal exam. Your doctor can feel your prostate to find out whether it’s hard, or whether there are noticeable nodules. Then, rather than getting a biopsy done right away, consider getting a 3D-color Doppler ultrasound done first. For more information, please see my previous article, “How to Survive Prostate Cancer Without Surgery, Drugs or Radiation.”

To Prevent Cancer, Remember the Basics

Remember, your lifestyle can be more or less predictive of your cancer risk, so always start with the basics: Make sure you’re eating a nutrient-dense, non-toxic diet, which basically means ditching processed foods and focusing your diet around whole, fresh foods, ideally organically grown to avoid toxic pesticides that can increase your cancer risk.

Avoid animal products from concentrated animal feeding operations (CAFOs), as these animals are routinely raised with hormones, antibiotics and glyphosate-contaminated genetically engineered (GE) grains. Processed foods in general are anathema to good health, but particularly when you’re trying to prevent or heal cancer.

If a toxicology screen reveals high amounts of toxins in your body, a detoxification program would be in order. My absolute favorite form of detox is a full spectrum infrared sauna that has near-infrared frequencies and low EMF. Most infrared saunas have only far-infrared and are high in EMF. I believe selecting a sauna that keeps your head out of the heat is also important and I am working on developing one that meets this spec early next year.

You may also want to do a saliva panel to check your hormone levels. Low testosterone and/or excessive estrogen may be factors that need to be corrected. For low testosterone, you could start out with herbal supplements, high intensity exercise and/or intermittent fasting rather than jumping right into testosterone replacement therapy.

Also remember to check your vitamin D. For optimal health and cancer prevention, make sure you maintain a clinically relevant level of 40 to 60 ng/ml year-round. If you already have cancer, you may want to consider an even higher level.

You Can Prevent, and Beat, Prostate Cancer

Checking for insulin resistance goes along with your dietary intervention. If you’re insulin resistant, you need to be particularly careful about cutting down on sugar, ideally limiting your total fructose consumption from all sources to less than 15 grams per day. Thankfully, nutritional ketosis is one of the best ways to improve your insulin receptor sensitivity.

If you are overweight, you can use fasting as a very powerful therapeutic tool and the best resource for that is Dr. Jason Fung’s book “The Complete Guide to Fasting.” I would strongly encourage you to listen to my recent interview with Fung.

Another powerful tool to maintain nutritional ketosis is intermittent fasting. Nutritional ketosis is not something you maintain for your entire life, but is part of a feast and famine cycling that allows your body to repair and regenerate while maintaining its ability to burn fat.

Once you’ve cleaned up your diet, adding certain herbal supplements such as saw palmetto (with or without astaxanthin) and Ashwagandha may help support your prostate health.

These are just some suggestions that can minimize your risk of prostate cancer and help treat it should you be diagnosed. There are many others. For example, increasing selenium and magnesium while decreasing calcium may reduce your prostate cancer risk, and simple strategies such as prostate massage can be a helpful adjunct to prostate cancer treatment.

The main take-home message is that you have options when it comes to prevention, diagnostics and treatment. Also remember that, while any cancer diagnosis is distressing, when it comes to prostate cancer, you likely do have time to pursue alternative routes of treatment. Rarely is it necessary to jump right into drugs, surgery or radiation. So try not to let fear rule your decision-making process.

How successful ? EBC46, injected directly into the tumor, can kill it in just 48 hours.

For more information and to be considered for a trial, click here.

Blushwood berries are the fruit of the blushwood tree, which is known to grow in only one region of the world: the rainforests of Far North Queensland, Australia.

These tropical trees are not found anywhere else on the globe, but grow in abundance near Australias northeastern tip.

These particular trees need very niche conditions to thriveconditions which can only be found in specific portions of Far North Queensland, Australia.

Considering their usefulness as proven by the latest cancer research published in PLOS One, some are wondering if they could be grown in a greenhouse environment, so that people all over the world could benefit from their cancer-killing properties.

Its been twenty-one years since the first study reported a possible link between elevated serum selenium and prostate cancer risk reduction. In the years since, research has continued to explore this minerals role in cancer risk reduction. A literature review in the journal Medicine released this week continues the steady stream of research supporting this viewpoint.
Seventeen of 1352 studies (up to Sept. 2016) were identified as suitable from PubMed, Embase, Medline, and the Cochrane Library. The final review included 6136 prostate cancer cases and >34,901 controls or participants.

Prostate cancer is the second most common form of cancer in men, and the sixth leading cause of cancer deaths in developed countries. Characterized by difficulty and pain in urination, increased frequency of urination and blood in urine this condition also results in embarrassments to affected individuals as urine leaks out while coughing or laughing. Although some of these symptoms might be because of an enlarged prostate, it is advised to screen for prostate cancer if one is over 50 years of age. It is estimated that by 2030, 1.7 million new cases and 499,000 fatalities might be because of this deadly disease (World journal of Surgical Oncology, 2012). This year alone, the American Cancer Society has estimated 161,360 new cases of prostate cancer and 26,730 deaths in the United States (www.cancer.org/cancer/prostate-cancer).

Prostate gland, a part of the male reproductive system, is a tiny walnut sized gland that performs the task of regulating the passage of semen and urine. The fluid secreted by the prostate gland makes up one third of the semen, protecting and nourishing the sperms. Urine and semen are released from the body through a tube like structure urethra that passes through the prostate gland, which controls this process with the help of numerous muscle fibers. Cancerous growth in such a vital organ can severely impact different physiological processes, besides causing threat to ones life.

Prostate cancer has an average diagnosis age of 66 years, with 6 out of 10 cases reported in men above the age of 65 years. It is generally treated through surgery, hormone therapy, radiation therapy, and chemotherapy. Although these treatments are successful, the toxic side effects of these procedures are of great concern. Alternative systems of medicines, like ayurveda, promise zero side effects with desired benefits, forcing many to go green. It is not surprising that some herbal drugs prepared using plant extracts are already being used to treat cancer. In fact, Taxol, a famous chemotherapy agent used for different types of cancers was extracted from the bark of Taxus brevifolia. Now, a research group led by Dr. M.B. Hiremath, Associate Professor at Karnataka University, Dharwad, has recently reported the anti-cancer potential of two medicinal plants Leea indica and Allophylus cobbe, against prostate cancer.

Leea indica, or bandicoot berry (kukur jihwa in Hindi) is a large, evergreen shrub, native to tropical India, Bangladesh, China, Bhutan, and Malaysia. It is used in traditional medicine to relieve headaches, skin problems, body aches and for its antidiabetic, antidiarrheal and antidysenteric properties. Allophylus cobbe, also called Indian allophylus, is a small shrub and commonly seen in the Western Ghats of India and used for treating bone fractures, inflammations, ulcers and wounds as a natural antiseptic. While these plant extracts have already shown cytotoxic properties on colon and breast cancer cells, this study is the first to examine the effects on prostate cancer.

The researchers of the study tested the extracts prepared by treating the leaves of the two plants in water, methanol and ethanol on cancerous cells of the prostate and found them to be very effective. During the study, we witnessed gradual deterioration of prostate cancer cells by undergoing morphological changes in shape and size and eventually reaching apoptosis (programmed cell death) after 72 hours of exposure to these natural extracts, shares Dr. Hiremath, talking about the effectiveness of these plant-based extracts. The results of their studies have been recently reported in two journals Cytotechnology and Integrative Medicine Research.

The researchers have reported the presence of a range of secondary plant metabolites like phenols, alkaloids, flavonoids and saponins in the leaves of the two plants. These metabolites have proven to be strong antioxidants that destroy harmful free radicals present in our body. Both the plant showed high phenolic content in our study. Interestingly, the antioxidant capacity of the plant extracts studied is also closely equivalent to the standard antioxidant agents like ascorbic acid, explains Dr. Hiremath about their interesting findings.

The researchers hope to soon test the efficiency of these extracts in humans through clinical trails. Our findings have shown positive results at in vitro level (outside human body). These outputs have given a positive stand point to take on further studies using living systems to establish the potential of these extracts to be used as therapeutic agent to fight prostate cancer, signs off Dr. Hiremath, detailing the future of the study.
Source: Yahoo! News Australia

New research from The University of Texas at Austin identifies several natural compounds found in food, including turmeric, apple peels and red grapes, as key ingredients that could thwart the growth of prostate cancer, the most common cancer afflicting U.S. men and a key area of focus during Mens Health Month, which public health advocates celebrate in June, reports the University of Texas in Austin. Published online this week in Precision Oncology, the new paper uses a novel analytical approach to screen numerous plant-based chemicals instead of testing a single agent as many studies do, discovering specific combinations that shrink prostate cancer tumors.
Ursolic acid from apple peels
Curcumin from turmeric
Resveratrol from red grapes
The new research paper also demonstrates how the plant-based chemicals work together. Combining ursolic acid with either curcumin or resveratrol prevents cancer cells from gobbling something that they need to grow, glutamine. This is a neat solution: blocking the uptake of a nutrient needed by prostate cancer cells with nutrients that are commonly in the human diet.

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